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Lasiokaurin

Cat. No. M16507
Lasiokaurin Structure
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Biological Activity

Lasiokaurin

Chemical Information
CAS Number 28957-08-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ling-Xia Zhang, et al. Zhongguo Zhong Yao Za Zhi. [Studies on chemical constituents of Isodon henryi]

[2] Li-Ping Dai, et al. Nat Prod Res. Isolation and purification of diterpenoids from the aerial parts of Isodon excisoides target-guided by UPLC-LTQ-Orbitrap-MS

[3] Da-Hong Li, et al. Arch Pharm Res. Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects

[4] Yingfeng Du, et al. J Chromatogr A. A sensitive analysis method for 7 diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study of Isodon serra extract

[5] Lan Ding, et al. Nat Prod Res. Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant

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