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Lansoprazole

Cat. No. M5728
Lansoprazole Structure
Synonym:

A-65006, AG-1749

Size Price Availability Quantity
200mg USD 70  USD70 In stock
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Quality Control
Biological Activity

Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 369.36
Formula C16H14F3N3O2S
CAS Number 103577-45-3
Purity 99.94%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

[1] Lang JE, et al. Ann Am Thorac Soc. Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Lansoprazole, A-65006, AG-1749 supplier, Potassium Channel, inhibitors

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