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IDH1 Inhibitor 7

Cat. No. M54534

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IDH1 Inhibitor 7 Structure

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Quality Control & Documentation
Biological Activity

IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC50 of less than 100 nM.

Chemical Information
Molecular Weight 459.47
Formula C22H24F3N7O
CAS Number 2135309-56-5
Form Solid
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Related Isocitrate Dehydrogenase (IDH) Products
Mutant IDH1-IN-4

Mutant IDH1-IN-4 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH 1) with an IC50 value of ≤ 0.5 μM for mutant IDH 1 in R132H, HT1080 and U87R132H cells.

(S,S)-GSK321

(S,S)-GSK321 is the (S,S)-enantiomer of GSK321.GSK321 is a potent inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme.

IDH1 Inhibitor 1

IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-permeable, selective mutant IDH1 inhibitor that inhibits IDH1R132H, IDH1R132C, and IDH1WT with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM, respectively. possesses antitumor activity.

(R,R)-GSK321

(R,R)-GSK321 is an isomer of GSK321 and a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM.

IDH1 Inhibitor 2

IDH1 Inhibitor 2 is a potent wild-type IDH1 inhibitor that acts through covalent modification of His315 and has an IC50 value of 110 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: IDH1 Inhibitor 7 supplier, Isocitrate Dehydrogenase (IDH), inhibitors, activators

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