Hydroquinone is an inhibitor and antioxidant used as a synthetic intermediate in dyes, engine fuels, and oils. It also has antioxidant properties and produces toxic effects in multiple organs, especially the kidneys. It can be used to construct animal models of vitiligo.
| Molecular Weight | 110.11 |
| Formula | C6H6O2 |
| CAS Number | 123-31-9 |
| Solubility (25°C) | Water ≥ 40 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] T Searle, et al. Clin Exp Dermatol. Hydroquinone: myths and reality
[4] J J Nordlund, et al. J Eur Acad Dermatol Venereol. The safety of hydroquinone
[5] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Hydroquinone
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