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GSK620

Cat. No. M10760

All AbMole products are for research use only, cannot be used for human consumption.

GSK620 Structure
Size Price Availability Quantity
5mg USD 94  USD94 In stock
10mg USD 148  USD148 In stock
25mg USD 295  USD295 In stock
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Biological Activity

GSK620 is a potent orally active pan-BD2 inhibitor with good broad-spectrum selectivity, developability, and in vivo oral pharmacokinetics, and is highly selective against the BET-BD2 family protein, with a selectivity of more than 200 times that of all other BET bromodomains. GSK620 exhibits an anti-inflammatory phenotype in human whole blood.

Chemical Information
Molecular Weight 325.36
Formula C18H19N3O3
CAS Number 2088410-46-0
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jonathan T Seal, et al. J Med Chem. Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors

[2] Francesco Rianjongdee, et al. J Med Chem. Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit

[3] Helen E Aylott, et al. J Med Chem. Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors

[4] Jonathan T Seal, et al. J Med Chem. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor

[5] Omer Gilan, et al. Science. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

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Keywords: GSK620 supplier, Epigenetic Reader Domain, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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