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GL67 pentahydrochloride

Cat. No. M25512
GL67 pentahydrochloride Structure
Synonym:

N4-Spermine cholesteryl carbamate pentahydrochloride

Size Price Availability
5mg USD 200  USD200 4-7 Days
10mg USD 350  USD350 4-7 Days
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Quality Control & Documentation
Biological Activity

GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection.

Chemical Information
Molecular Weight 797.29
Formula C38H75Cl5N4O2
CAS Number 179075-30-0 (free base)
Solubility (25°C) DMSO 4 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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