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Famitinib (SHR1020), an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib exerts powerful antitumor activity in human gastric cancer cells and xenografts. Famitinib triggers apoptosis.
| Molecular Weight | 410.48 |
| Formula | C23H27FN4O2 |
| CAS Number | 1044040-56-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 4.17 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Timothy Thomas. Nat Rev Urol. Camrelizumab plus famitinib to treat RCC
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