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DSPE-PEG(2000)-MAL

Cat. No. M13351
DSPE-PEG(2000)-MAL Structure
Synonym:

DSPE-PEG(2000) Maleimide

Size Price Availability Quantity
50mg USD 175  USD175 In stock
100mg USD 285  USD285 In stock
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Quality Control & Documentation
Biological Activity

DSPE-PEG-MAL is one of the reactive phospholipid PEG reagents that can react with sulfhydryl group (mercaptan, -SH). DSPE (1, 2-distearyl-Sn-glycerol 3-phosphate ethanolamine) is a highly hydrophobic saturated 18C phospholipid.

Chemical Information
Molecular Weight 1047.35
Formula C53N4O14PH99
CAS Number 474922-22-0
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nitin Bharat Charbe, et al. Acta Pharm Sin B. Small interfering RNA for cancer treatment: overcoming hurdles in delivery

[2] Liang Kong, et al. Int J Nanomedicine. Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC

[3] Shima Gholizadeh, et al. Int J Pharm. E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells

[4] Mira Oswald, et al. Int J Pharm. Determination of the activity of maleimide-functionalized phospholipids during preparation of liposomes

[5] K Maruyama. Biol Pharm Bull. In vivo targeting by liposomes

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Keywords: DSPE-PEG(2000)-MAL, DSPE-PEG(2000) Maleimide supplier, Cell Transfection, inhibitors, activators


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