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Cat. No. M19463
DNJ Structure

1-Deoxynojirimycin hydrochloride

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active α-glucosidase inhibitor.

Chemical Information
Molecular Weight 199.63
Formula C6H14ClNO4
CAS Number 73285-50-4
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Soo Takasu, et al. Food Funct. Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

[2] Lukas Schmauder, et al. Sci Rep. Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90

[3] Lucia Marchetti, et al. Plants (Basel). Determination of 1-Deoxynojirimycin (1-DNJ) in Leaves of Italian or Italy-Adapted Cultivars of Mulberry ( Morus by HPLC-MS

[4] Tian-Tian Lu, et al. Eur J Med Chem. Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives

[5] Haijun Wang, et al. Curr Med Chem. 1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

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Abmole Inhibitor Catalog

Keywords: DNJ, 1-Deoxynojirimycin hydrochloride supplier, Glucosidase, inhibitors, activators

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