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Dihydroresveratrol

Cat. No. M17196
Dihydroresveratrol Structure
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Biological Activity

Dihydroresveratrol

Chemical Information
CAS Number 58436-28-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qiang-Guo Ji, et al. Rapid Commun Mass Spectrom. Detection and structural characterization of the metabolites of dihydroresveratrol in rats by liquid chromatography coupled to high-resolution tandem mass spectrometry

[2] Kathrin Pallauf, et al. Sci Rep. Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice

[3] Sara Vitalini, et al. Curr Med Chem. Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity

[4] Chisato Oode, et al. Carbohydr Res. Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators

[5] Thomas Walle. Ann N Y Acad Sci. Bioavailability of resveratrol

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