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Dalotuzumab

Cat. No. M24531

All AbMole products are for research use only, cannot be used for human consumption.

Dalotuzumab Structure
Synonym:

MK-0646; h7C10

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Quality Control & Documentation
Biological Activity

Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer drugs such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo.

Chemical Information
CAS Number 1005389-60-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Xiao Qu, et al. Oncotarget. Update of IGF-1 receptor inhibitor (ganitumab, dalotuzumab, cixutumumab, teprotumumab and figitumumab) effects on cancer therapy

[2] Francesco Sclafani, et al. Int J Cancer. Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial

[3] Didier Frappaz, et al. Eur J Cancer. Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours

[4] Teresa Moran, et al. Exp Hematol Oncol. Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: a phase I/II randomized trial

[5] Mario Scartozzi, et al. Curr Opin Mol Ther. Dalotuzumab, a recombinant humanized mAb targeted against IGFR1 for the treatment of cancer

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Keywords: Dalotuzumab, MK-0646; h7C10 supplier, IGF-1R, inhibitors, activators

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