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Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
| Molecular Weight | 566.58 |
| CAS Number | 857036-77-2 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL Water ~2 mg/mL |
| Storage | 2-8°C, dry, sealed |
[1] Simon N Black, et al. Cediranib Maleate-From Crystal Structure Toward Materials Control
[2] Weifeng Tang, et al. Clinical Pharmacokinetics and Pharmacodynamics of Cediranib
| Related VEGFR/PDGFR Products |
|---|
| SU5208
SU5208 inhibits vascular endothelial growth factor receptor-2 (VEGFR2). |
| VEGFR-IN-1
VEGFR-IN-1 is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively. |
| (Z)-Orantinib
(Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC50s of 2.1, 0.008, and 1.2 µM, respectively. |
| (Rac)-SAR131675
(Rac)-SAR131675 is the racemate of SAR131675. |
| AGL 2043
AGL 2043 is an effective inhibitor of PDGFR (IC50=0.8 μM) and TEL-PDGFR kinases, as well as FLT3 and KIT kinases. |
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