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CCT251455

Cat. No. M28331

All AbMole products are for research use only, cannot be used for human consumption.

CCT251455 Structure

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Quality Control & Documentation

Purity: ≥99.0%
COA
MSDS

Product Information

Biological Activity

CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.

Chemical Information

Molecular Weight	503.98
Formula	C26H26ClN7O2
CAS Number	1400284-80-1
Form	Solid
Solubility (25°C)	DMSO 100 mg/mL (ultrasonic)
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Kai Chen, et al. J Biomol Struct Dyn. Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation

[2] Paolo Innocenti, et al. J Med Chem. Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach

[3] Mark D Gurden, et al. Cancer Res. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance

[4] Sébastien Naud, et al. J Med Chem. Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)

Related Mps1/TTK Products
Luvixasertib hydrochloride CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro.
Mps1-IN-6 Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM.
RMS-07 RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region.
NMS-P715 NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.

Catalog

Abmole Inhibitor Catalog

Keywords: CCT251455 supplier, Mps1/TTK, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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