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Britannilactone

Cat. No. M17533
Britannilactone Structure
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Biological Activity

Britannilactone

Chemical Information
CAS Number 33620-72-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hui Xie, et al. Zhongguo Zhong Yao Za Zhi. [Characteristic chromatogram and index components content of substance benchmark of Xuanfu Daizhe Decoction]

[2] Ping Xiang, et al. Nat Prod Commun. Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula britannica

[3] Soo-Jin Choo, et al. Arch Pharm Res. Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells

[4] Jrn Merten, et al. Chemistry. Total synthesis of the cytotoxic 1,10-seco-eudesmanolides britannilactone and 1,6-O,O-diacetylbritannilactone

[5] Yue-Ping Liu, et al. Phytomedicine. 1,6-O,O-diacetylbritannilactones inhibits IkappaB kinase beta-dependent NF-kappaB activation

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