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BI 894999

Cat. No. M20727

All AbMole products are for research use only, cannot be used for human consumption.

BI 894999 Structure

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Quality Control & Documentation
Biological Activity

BI 894999 is a potent and selective BET inhibitor with IC50 of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI 894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1.

Chemical Information
Molecular Weight 429.51
Formula C25H27N5O2
CAS Number 1660117-38-3
Solubility (25°C) DMSO 86 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ulrike Tontsch-Grunt, et al. Br J Cancer. Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic

[2] Daniel Gerlach, et al. Oncogene. The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

[3] Ulrike Tontsch-Grunt, et al. Cancer Lett. Synergistic activity of BET inhibitor BI 894999 with PLK inhibitor volasertib in AML in vitro and in vivo

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  Catalog
Abmole Inhibitor Catalog




Keywords: BI 894999 supplier, Epigenetic Reader Domain, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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