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ABP 215

Cat. No. M24674
ABP 215 Structure
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Quality Control & Documentation
Biological Activity

ABP 215 (Bevacizumab-awwb), a Bevacizumab (Bevacizumab biosimilar, is a humanized IgG1 monoclonal antibody targeting VEGFA (VEGFR). ABP 215 has anticancer effects, and can be used metastatic colorectal cancer (mCRC) research.

Chemical Information
CAS Number 1438851-35-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jerome Goldschmidt, et al. Oncol Ther. The Totality of Evidence and Use of ABP 215, a Biosimilar to Bevacizumab

[2] Michael Thomas, et al. Immunotherapy. Totality of evidence in the development of ABP 215, an approved bevacizumab biosimilar

[3] Nicholas Thatcher, et al. Clin Cancer Res. Efficacy and Safety of the Biosimilar ABP 215 Compared with Bevacizumab in Patients with Advanced Nonsquamous Non-small Cell Lung Cancer (MAPLE): A Randomized, Double-blind, Phase III Study

[4] No authors listed. Bevacizumab

[5] Neungseon Seo, et al. MAbs. Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab

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  Catalog
Abmole Inhibitor Catalog




Keywords: ABP 215 supplier, VEGFR/PDGFR, inhibitors, activators


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