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2-Aminoethyl diphenylborinate (2-APB)

Cat. No. M9600

All AbMole products are for research use only, cannot be used for human consumption.

2-Aminoethyl diphenylborinate (2-APB) Structure
Synonym:

2-APB

Size Price Availability Quantity
10mM*1mL in DMSO USD 35  USD35 In stock
1mg USD 18  USD18 In stock
5mg USD 30  USD30 In stock
10mg USD 35  USD35 In stock
25mg USD 60  USD60 In stock
50mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R, and regulate IP3-induced calcium release. 2-Aminoethyl diphenylborinate (2-APB) inhibits the SOC channel activity and activates TRP channel at higher concentrations.

Chemical Information
Molecular Weight 225.09
Formula C14H16BNO
CAS Number 524-95-8
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mehmet Gazi Boyac, et al. World Neurosurg. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study

[2] Kenji Takahashi, et al. Exp Cell Res. Molecular Mechanism of 2-APB-induced Ca²⁺ Influx in External Acidification in PC12

[3] Gergely Kovacs, et al. Cell Calcium. Inhibition of the Human Epithelial Calcium Channel TRPV6 by 2-aminoethoxydiphenyl Borate (2-APB)

[4] L Missiaen, et al. Cell Calcium. 2-Aminoethoxydiphenyl Borate Affects the Inositol 1,4,5-trisphosphate Receptor, the Intracellular Ca2+ Pump and the Non-Specific Ca2+ Leak From the Non-Mitochondrial Ca2+ Stores in Permeabilized A7r5 Cells

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Keywords: 2-Aminoethyl diphenylborinate (2-APB), 2-APB supplier, Calcium Channel, inhibitors, activators

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