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16-Dehydropregnenolone

Cat. No. M22434
16-Dehydropregnenolone Structure
Size Price Availability Quantity
200mg USD 220  USD220 In stock
1g USD 490  USD490 In stock
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Quality Control & Documentation
Biological Activity

16-Dehydropregnenolone

Chemical Information
Molecular Weight 314.47
Formula C21H30O2
CAS Number 1162-53-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Pushpendra Awadhiya, et al. Pol J Microbiol. Bioconversion of 16-dehydropregnenolone Acetate to Exclusively 4-androstene-3,17-dione by Delftia acidovorans MTCC 3363

[2] Rachumallu Ramakrishna, et al. J Steroid Biochem Mol Biol. 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters

[3] Agnieszka Wojtkielewicz, et al. Steroids. A study on the reaction of 16-dehydropregnenolone acetate with 2-aminobenzimidazole

[4] Yangyang Sun, et al. Pharm Dev Technol. Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration

[5] T K Kwan, et al. FEBS Lett. Identification of 16-dehydropregnenolone as an intermediate in 16-androstene biosynthesis in neonatal porcine testicular microsomes

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