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1,5-Dihydroxyxanthone

Cat. No. M17888
1,5-Dihydroxyxanthone Structure
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Biological Activity

1,5-Dihydroxyxanthone

Chemical Information
CAS Number 14686-65-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sasa Ponguschariyagul, et al. Nat Prod Res. Caloinophyllin A, a new chromanone derivative from Calophyllum inophyllum roots

[2] Susawat Duangsrisai, et al. Molecules. Antibacterial and EGFR-tyrosine kinase inhibitory activities of polyhydroxylated xanthones from Garcinia succifolia

[3] Nawong Boonnak, et al. Acta Crystallogr Sect E Struct Rep Online. Racemic 2'-hydroxy-4',4'-dimethylpyran-1,5-dihydroxyxanthone monohydrate

[4] J Xu Kelly, et al. J Inorg Biochem. A spectroscopic investigation of the binding interactions between 4,5-dihydroxyxanthone and heme

[5] C N Lin, et al. J Pharm Pharmacol. Synthesis and anti-inflammatory effects of xanthone derivatives

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