| Cat.No. | Name | Information |
|---|---|---|
| M1721 | AZD4547 | AZD4547 is a potent, selective and orally active pan-FGFR inhibitor with IC50s of 0.2. 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. |
| M1840 | BGJ398 (Infigratinib) | BGJ398 (Infigratinib) is a potent and selective FGFR kinase inhibitor with IC50 values of 0.9 nM, 1.4 nM, 1 nM and 60 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. |
| M9715 | Erdafitinib | Erdafitinib (JNJ-42756493) is a potent and selective orally bioavailable, pan FGFR inhibitor with potential antineoplastic activity. |
| M43509 | S6K2-IN-1 | S6K2-IN-1 is a S6K2 inhibitor (IC50: 22 nM). |
| M43508 | FGFR4-IN-14 | FGFR4-IN-14 is a FGFR4 inhibitor (IC50: 2.4 nM. |
| M43507 | FGFR1 inhibitor-10 | FGFR1 inhibitor-10 is an FGFR1 inhibitor (IC50: 28 nM). |
| M43506 | FGFR1 inhibitor-8 | FGFR1 inhibitor-8 is a FGFR1 inhibitor (IC50s: 0.5 nM). |
| M43505 | Formononetin-d3-1 | Formononetin-d3-1 is the deuterium-labeled Formononetin. |
| M43504 | FGFR1 inhibitor-9 | FGFR1 inhibitor-9 is an FGFR1 inhibitor (IC50s: 0.85 nM). |
| M43503 | FGFR4-IN-16 | FGFR4-IN-16 (CY-15-2) is a covalent inhibitor of FGFR-4 for cancer research. |
| M43502 | FGFR1 inhibitor 7 | FGFR1 inhibitor 7 is an inhibitor of FGFR1 Tyrosine Kinase with IC50 value of 0.33 nM. |
| M43501 | Resigratinib | Resigratinib (KIN-3248) is a FGFR tyrosine kinase inhibitor, with antineoplastic effect. |
| M43500 | LC-MB12 | LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. |
| M43499 | Irpagratinib | Irpagratinib (ABSK011) is a potentially best-in-class, orally active fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor targeting FGFR4 (IC50<10 nM). |
| M40986 | NGM-313 | NGM-313 is a β-Klotho/FGFR1c-targeted monoclonal antibody for studies related to non-alcoholic steatohepatitis (NASH). |
| M40984 | BOS-580 | BOS-580 is an FGF21 analog and modulator for studies related to non-alcoholic steatohepatitis (NASH). |
| M40899 | LOXO-435 | LOXO-435 is a highly selective fibroblast growth factor receptor-3 (FGFR3) antagonist that can be used in a variety of tumor-related studies. |
| M40522 | Pegozafermin | Pegozafermin is a long-acting glycosylated fibroblast growth factor 21 (FGF21) analog that may be used in studies related to non-alcoholic steatohepatitis (NASH) and hypertriglyceridemia. |
| M30269 | Surfen dihydrochloride | Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection. |
| M28979 | E7090 succinate | E7090 succinate is an orally available, selective and potent inhibitor of FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC50 values of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/2/3/4, respectively. |
| M28863 | PD-089828 | PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 µM). PD-089828 also inhibits MAPK with an IC50 of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity. |
| M28710 | E7090 | E7090 is an orally available, potent, and selective FGFR inhibitor with IC50s of 0.71 nM, 0.50 nM, 1.2 nM, and 120 nM for FGFR1/FGFR2/FGFR3/FGFR4, respectively. |
| M28061 | FIIN-1 | FIIN-1 is a potent, irreversible, selective FGFR inhibitor. FIIN-1 binds to FGFR1/2/3/4 and Flt1/4 with Kds of 2.8/6.9/5.4/120 nM and 32/120 nM respectively. The biochemical IC50s of FIIN-1 are 9.2, 6.2, 11.9, and 189 nM against FGFR1/2/3/4, respectively. |
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