|M9909||Eltanexor||Eltanexor, also known as KPT-8602, is a second-generation exportin-1 (CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines.|
|M3152||KPT-330||KPT-330 is a first-in-class, oral, selective inhibitor of Nuclear Export (SINE) compound, works by binding to and inhibiting the nuclear export protein XPO1 (also known as CRM1).|
|M21722||Felezonexor (CBS9106)||Felezonexor (CBS9106; SL-801) is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity without affecting CRM1 mRNA levels. Felezonexor is also a reversible inhibitor of XPO1, inhibits nuclear export by covalently binding to Cys528 as well as by inducing the degradation of XPO1.|
|M6230||Verdinexor||Verdinexor (KPT-335) is an orally bioavailable, selective XPO1/CRM1 inhibitor.|
|M2795||KPT-276||KPT-276 is an orally bioavailable selective CRM1 inhibitor.|
|M2794||KPT-185||KPT-185 is a selective CRM1 inhibitor.|
|M28308||KPT-251||KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity.|
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