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TPI-1

Cat. No. M9403
TPI-1 Structure
Synonym:

Tyrosine Phosphatase Inhibitor 1

Size Price Availability Quantity
10mg USD 232 In stock
50mg USD 722 In stock
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Quality Control
Biological Activity

TPI-1 is a SHP-1 inhibitor, inhibits recombinant SHP-1 with an IC50 of 40 nM. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505.

In vivo, TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 253.08
Formula C12H6Cl2O2
CAS Number 79756-69-7
Purity 99.55%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C
References

Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents.
Kundu S, et al. J Immunol. 2010 Jun 1;184(11):6529-36. PMID: 20421638.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TPI-1, Tyrosine Phosphatase Inhibitor 1 supplier, Phosphatase, inhibitors

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