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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9898 | TNO155 | TNO155 is a potent and selective, orally active allosteric inhibitor of wild-type SHP2 with IC50 of 0.011 µM. |
| M9699 | KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 0.25 μM, which protects neurons from cerebral ischemic injury. |
| M9518 | BN82002 | BN82002, also known as CDC25 Phosphatase Inhibitor I, is a potent, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). |
| M9513 | BTdCPU | BTdCPU is an potent activator of HRI, it promotes eIF2α phosphorylation and induced apoptosis in resistant cell. |
| M9467 | F1063-0967 | F1063-0967 is a novel inhibitor of dual-specificity phosphatase 26 (DUSP26), inducing apoptosis in IMR-32 cell line. |
| M9403 | TPI-1 | TPI-1 is a SHP-1 inhibitor, inhibits recombinant SHP-1 with an IC50 of 40 nM. |
| M9231 | RMC-4550 | RMC-4550 is a potent and selective SHP2 inhibitor, with an IC50 of 0.583 nM. |
| M9190 | β-Glycerol phosphate disodium salt pentahydrate | β-Glycerol phosphate disodium salt pentahydrate is a potent protein phosphatase and tensin homolog (PTEN) inhibitor. |
| M7533 | SHP099 hydrochloride | SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. |
| M7060 | NSC 95397 | NSC 95397 is a selective Cdc25 dual specificity phosphatase inhibitor. |
| M6314 | SHP099 | SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. |
| M6300 | (-)-p-Bromotetramisole Oxalate | (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. |
| M5195 | Okadaic acid | Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively. |
| M5102 | PTP1B-IN-2 | PTP1B-IN-2 is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. |
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M2499 | CCT007093 | CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
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