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Phosphatase Phosphatase


Cat.No.  Name Information
M2849 Microcystin-LR Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
M14498 TCS 401 TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
M14496 SBI-425 SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
M14495 Rosiptor Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
M14494 Sodium metatungstate Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively.
M14493 MSI-1436 lactate MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).
M14492 MB05032 MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
M14491 β-Glycerophosphate disodium salt hydrate β-Glycerophosphate disodium salt hydrate, an endogenous metabolite, is a phosphatase inhibitor.
M14490 BCI hydrochloride BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP).
M14489 DT-061 DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
M14488 DIPQUO DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.
M14487 Calyculin A Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.
M14486 BN82002 hydrochloride BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family.
M14485 BCI BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5.
M14484 ARL67156 trisodium salt hydrate ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase.
M14483 ARL67156 trisodium salt ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
M14482 Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
M14481 3α-Aminocholestane 3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.
M11444 ABBV-CLS-484 Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity.
M11433 PTP1B-IN-1 Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.
M11432 Razuprotafib Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM).

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