Phosphatase Phosphatase

Inhibitors

Cat.No.	Name	Information
M2849	Microcystin-LR	Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.
M14498	TCS 401	TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
M14496	SBI-425	SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.
M14495	Rosiptor	Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
M14494	Sodium metatungstate	Sodium metatungstate (Sodium polyoxotungstate) is a potent ecto-nucleoside triphosphate diphosphohydrolase (ENTPDase) inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively.
M14493	MSI-1436 lactate	MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).
M14492	MB05032	MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
M14491	β-Glycerophosphate disodium salt hydrate	β-Glycerophosphate disodium salt hydrate, an endogenous metabolite, is a phosphatase inhibitor.
M14490	BCI hydrochloride	BCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP).
M14489	DT-061	DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
M14488	DIPQUO	DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.
M14487	Calyculin A	Calyculin A ((-)-Calyculin A) is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 2 nM and 0.5-1 nM, respectively.
M14486	BN82002 hydrochloride	BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family.
M14485	BCI	BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5.
M14484	ARL67156 trisodium salt hydrate	ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase.
M14483	ARL67156 trisodium salt	ARL67156 trisodium salt is an inhibitor of ecto-ATPase.
M14482	Aloe-emodin-8-O-β-D-glucopyranoside	Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM.
M14481	3α-Aminocholestane	3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM.
M11444	ABBV-CLS-484	Abbv-cls-484 is a potent inhibitor of PTPN1 or PTPN2 with subnanomolar activity.
M11433	PTP1B-IN-1	Ptp1b-in-1 is a small molecule inhibitor of PTP1B with an IC50 value of 1.6mm, and is often used as a parent nucleus derived from analogues.
M11432	Razuprotafib	Razuprotafib (AKB-9778) is an effective selective inhibitor of VE-PTP (HPTPß) catalytic activity (IC50=17 pM).

Signaling Pathways

Product Type

Phosphatase Phosphatase

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