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Microcystin-LR

Cat. No. M2849
Microcystin-LR Structure
Size Price Availability
100ug USD 200 Out of stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1.

Product Citations
Customer Product Validations & Biological Datas
Source Comp Biochem Physiol C Toxicol Pharmacol (2018). Figure 6. MC-LR (AbMole BioScience,Shanghai, China)
Method qRT-PCR
Cell Lines fish
Concentrations 2 μg/L, 20 μg/L
Incubation Time 30 days
Results In the brain, the transcription of the two receptors was increased after MC-LR treatment, whereas in the liver and spleen, it was markedly upregulated at low MC-LR concentration (2 μg/L) and downregulated at high MC-LR concentration (20 μg/L) compared with the control group
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 995.17
Formula C49H74N10O12
CAS Number 101043-37-2
Purity >95%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Microcystin-LR supplier, inhibitors

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