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Embelin

Cat. No. M5611
Embelin Structure
Synonym:

Embelic acid; Emberine; NSC 91874

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Embelin is a cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50 = 4.1 uM in a competitive binding assay with Smac peptide).

Chemical Information
Molecular Weight 294.39
Formula C17H26O4
CAS Number 550-24-3
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang T, et al. Cell Biochem Biophys. Embelin sensitizes acute myeloid leukemia cells to TRAIL through XIAP inhibition and NF-κB inactivation.

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  Catalog
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Keywords: Embelin, Embelic acid; Emberine; NSC 91874 supplier, IAP, inhibitors, activators


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