Free shipping on all orders over $ 500

ARRY-520

Cat. No. M3216
ARRY-520 Structure
Size Price Availability Quantity
5mg USD 170 In stock
10mg USD 300 In stock
50mg USD 780 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro. ARRY-520 had low nanomolar antiproliferative activity in tumor cell lines. ARRY-520 effectively reduced cell viability in a time-dependent manner in the Type II EOC cell lines A2780, CP70, and 01–28 but had minimal effect on Paclitaxel-resistant Type I EOC cell lines R182, 01–19b, and R1140. In addition, following ARRY-520 treatment, a significant increase in the activity of caspases- 8, 9, and 3 was observed in a time-dependent manner.ARRY-520 is able to induce the activation of caspase-2 in a time-dependent manner similar to that observed with the other caspases-9, -8, and -3. ARRY-520 is able to down-regulate the constitutive MCP-1 secretion. In addition, ARRY-520 induced a decrease in tumor kinetics in a dose-dependent manner.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 420.48
Formula C20H22F2N4O2S
CAS Number 885060-09-3
Purity >99%
Solubility DMSO
Storage at -20°C
Related Kinesin Products
Monastrol

Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles.

AZD4877

AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity.

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

GSK923295

GSK923295 is an allosteric inhibitor of CENP-E with Ki value of 3.2 nM.

AZ3146

AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor with IC50 of 35 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ARRY-520 supplier, Kinesin, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.