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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M10666 | CW069 | CW069 is an allosteric inhibitor of HSET with IC50 of 75 μM, it showed marked activity against HSET in vitro. |
| M9174 | ARQ 621 | ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. |
| M8930 | EMD534085 | EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC50 of 8 nM. |
| M8918 | BAY 1217389 | BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. |
| M7876 | K-858 | Eg5 is a key protein involved in the formation of bipolar spindles. |
| M5230 | Monastrol | Monastrol is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) which is essential for maintaining separation of the half-spindles. |
| M3672 | AZD4877 | AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. |
| M3216 | ARRY-520 | ARRY-520 is a potent and selective kinesin spindle protein (KSP) inhibitor with an IC50 of 15 nM for A2780, CP70 and 01-28 cell lines in vitro. |
| M2868 | MPI-0479605 | MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. |
| M2171 | GSK923295 | GSK923295 is an allosteric inhibitor of CENP-E with Ki value of 3.2 nM. |
| M2128 | AZ3146 | AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor with IC50 of 35 nM. |
| M1983 | SB-743921 | SB-743921 is a highly potent and active KSP inhibitor with a Ki of 0.1 nM for KSP (Eg5). |
| M1786 | Ispinesib | Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM. |
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