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MPI-0479605

Cat. No. M2868
MPI-0479605 Structure
Size Price Availability
5mg USD 240 Out of stock
10mg USD 390 Out of stock
50mg USD 1120 Out of stock
100mg USD 1600 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 407.51
Formula C22H29N7O
CAS Number 1246529-32-7
Purity >98%
Solubility DMSO
Storage at -20°C
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Monastrol

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MPI-0479605 supplier, Kinesin, inhibitors

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