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AZD4877

Cat. No. M3672
AZD4877 Structure
Size Price Availability
5mg USD 130 Out of stock
10mg USD 200 Out of stock
50mg USD 550 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZD4877 is a specific, potent inhibitor of Eg5. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly. AZD4877 is generally well-tolerated with pharmacodynamic evidence of target inhibition in circulating PBMCs. AZD4877 was generally tolerable in patients with advanced urothelial cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 503.66
Formula C28H33N5O2S
CAS Number 1176760-49-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer.
Jones R, et al. Invest New Drugs. 2013 Aug;31(4):1001-7. PMID: 23329066.

A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies.
Gerecitano JF, et al. Invest New Drugs. 2013 Apr;31(2):355-62. PMID: 22615058.

A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors.
Infante JR, et al. Cancer Chemother Pharmacol. 2012 Jan;69(1):165-72. PMID: 21638123.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD4877 supplier, Kinesin, inhibitors

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