|M5246||EW-7197||EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively.|
|M5038||SD-208||SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.|
|M5037||A 83-01||A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).|
|M5036||A 77-01||A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.|
|M4863||Kartogenin||Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.|
|M3918||Asiaticoside||Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica.|
|M2550||SB-505124||SB-505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively.|
|M2328||Pirfenidone||Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.|
|M2149||Astragaloside IV||Astragaloside IV is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs.|
|M2108||SB-525334||SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM.|
|M2081||LY2109761||LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor.|
|M2016||LY364947||LY364947 is a selective small molecule inhibitor of the TGFβ type I receptor kinase with IC50 of 59 nM.|
|M2000||GW788388||GW788388 is a potent selective inhibitor of TGF-beta type I receptor and ALK5 with IC50 values of 0.093 and 0.018 μM.|
|M1980||LY2157299||LY2157299 is a novel clinically relevant TBRI (ALK5 kinase) inhibitor with IC50 of 56 nM.|
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