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Kartogenin

Cat. No. M4863
Kartogenin Structure
Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 90 In stock
50mg USD 240 In stock
100mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes.Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 317.34
Formula C20H15NO3
CAS Number 4727-31-5
Purity >99%
Solubility DMSO 63 mg/mL
Water <1 mg/mL
Storage at -20°C
References

A stem cell-based approach to cartilage repair.
Johnson K, et.al Science. 2012 May;336(6082):717-21. PMID: 22491093.

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Keywords: Kartogenin supplier, TGF-beta, inhibitors

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