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SRI-011381 hydrochloride

Cat. No. M9088
SRI-011381 hydrochloride Structure

SRI011381 HCl

Size Price Availability
5mg USD 150 Custom Synthesis
10mg USD 260 Custom Synthesis
25mg USD 550 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SRI-011381 hydrochloride is a TGF-beta signaling agonist. SRI-011381 is a biologically active inducer of TGF-β signaling in cell culture and in vivo. SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 365.94
Formula C20H32ClN3O
CAS Number 1629138-41-5
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
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Keywords: SRI-011381 hydrochloride, SRI011381 HCl supplier, TGF-beta/Smad, inhibitors

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