Free shipping on all orders over $ 500

SRI-011381 hydrochloride

Cat. No. M9088
SRI-011381 hydrochloride Structure
Synonym:

SRI011381 HCl

Size Price Availability
5mg USD 150 Custom Synthesis
10mg USD 260 Custom Synthesis
25mg USD 550 Custom Synthesis
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SRI-011381 hydrochloride is a TGF-beta signaling agonist. SRI-011381 is a biologically active inducer of TGF-β signaling in cell culture and in vivo. SRI-011381 protects mice against kainic acid-induced excitotoxicity and neurodegeneration. SRI-011381 by oral gavage of 10, 30, and 75 mg/kg for 14 days resulted in significant changes in hematological endpoints, most notably reductions in red blood cells (RBCs), hematocrit and hemoglobin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 365.94
Formula C20H32ClN3O
CAS Number 1629138-41-5
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
Related TGF-beta/Smad Products
ITD-1

ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM).

R-268712

R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).

LY3200882

LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.

Disitertide

Disitertide is a TGF-β1 inhibitor.

SIS3

SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 with an IC50 of 3 µM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SRI-011381 hydrochloride, SRI011381 HCl supplier, TGF-beta/Smad, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.