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SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 329.48 |
| Formula | C20H31N3O |
| CAS Number | 1629138-41-5 |
| Purity | >99% |
| Solubility | DMSO ≥ 40 mg/mL |
| Storage | at -20°C |
| Related TGF-beta/Smad Products |
|---|
| BIBF0775
BIBF0775 is a potent and selective inhibitor of the transforming growth factor β receptor I (TGFβRI, Alk5) with an IC50 of 34 nM. |
| SB-4
SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. |
| SJ000291942
SJ000291942 is a bone morphogenic protein (BMP) signaling activator. |
| SM16
SM16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC50=64 nM). |
| ITD-1
ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM). |
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