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Pirfenidone

Cat. No. M2328
Pirfenidone Structure
Synonym:

AMR69

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 40  USD40 In stock
100mg USD 62  USD62 In stock
500mg USD 110  USD110 In stock
1g USD 165  USD165 In stock
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Quality Control
Biological Activity

Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. In RAW264.7 cells, Pirfenidone suppresses the proinflammatory cytokine TNF-α by a translational mechanism, which is independent of activation of the MAPK2, p38 MAPK, and JNK. In the murine endotoxin shock model, Pirfenidone potently inhibits the production of the proinflammatory cytokines, TNF-α, interferon-γ, and interleukin-6, but enhances the production of the anti-inflammatory cytokine, interleukin-10.

Product Citations
Customer Product Validations & Biological Datas
Source Int. J. Med. Sci (2020 Jul). Figure 4. Pirfenidone (Abmole Bioscience, TX, USA)
Method cell culture
Cell Lines HEK293 and C3H10T1/2 cell lines
Concentrations 1000 µg/mL
Incubation Time -
Results Moreover, pirfenidone could also significantly diminish the protein levels of OPN and OCN
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 185.22
Formula C12H11NO
CAS Number 53179-13-8
Purity 99.00%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

[1] Minoru Inomata, et al. Respir Res. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis

[2] Isabel Burghardt, et al. Biochem Biophys Res Commun. Pirfenidone inhibits TGF-beta expression in malignant glioma cells

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Keywords: Pirfenidone, AMR69 supplier, TGF-beta/Smad, inhibitors

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