Free shipping on all orders over $ 500

Pirfenidone

Cat. No. M2328
Pirfenidone Structure
Synonym:

AMR69

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 75 In stock
500mg USD 122 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 185.22
Formula C12H11NO
CAS Number 53179-13-8
Purity 100.00%
Solubility DMSO 20 mg/mL
Storage at -20°C
Related TGF-beta/Smad Products
ITD-1

ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM).

R-268712

R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).

LY3200882

LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.

SRI-011381 hydrochloride

SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Disitertide

Disitertide is a TGF-β1 inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pirfenidone, AMR69 supplier, TGF-beta/Smad, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.