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Src-bcr-Abl Src-bcr-Abl

Inhibitors

Cat.No.  Name Information
M2331 PP2 (AGL 1879) PP2 is a selective inhibitor of Src-family tyrosine kinases with >10,000-fold selectivity over ZAP-70 and JAK2.
M1712 FTY720 hydrochloride Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells.
M1701 Dasatinib Dasatinib (BMS-354825) is a small molecule inhibitor of both the SRC and BCR/ABL tyrosine kinases, with IC50's for the isolated kinases of 0.55 and 3.0 nM, respectively.
M1648 AP24534 Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor of BCR-ABL, PDGFRα, c-Src, c-Kit, FGFR and VEGFR.
M1799 Imatinib Mesylate Imatinib Mesylate is a Bcr-Abl tyrosine kinase inhibitor, with IC50 values of 2.9 and 3.9 μM for the inhibition of T-cell proliferation stimulated by PHA and DCs respectively.
M20833 Vodobatinib (K0706) Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.
M20763 DGY-06-116 DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.
M20707 RK 24466 RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively.
M20634 UM-164 UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.
M20633 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
M20580 HG-14-10-04 HG-14-10-04 is an inhibitor of ALK .
M20506 7-Hydroxy-4-chromone 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM.
M20466 Nilotinib hydrochloride Nilotinib hydrochloride is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
M20137 WAY-329689 WAY-329689 has ABL kinase inhibiting activities.
M20136 WAY-329686 WAY-329686 has ABL kinase inhibiting activities.
M20135 WAY-329685 WAY-329685 has ABL kinase inhibiting activities.
M20128 WAY-329424 WAY-329424 has ABL kinase inhibiting activities.
M20127 WAY-329423 WAY-329423 has ABL kinase inhibiting activities.
M20126 WAY-329412 WAY-329412 has ABL kinase inhibiting activities.
M20125 WAY-329410 WAY-329410 has ABL kinase inhibiting activities.
M20124 WAY-329356 WAY-329356 has ABL kinase inhibiting activities.
M20123 WAY-329341 WAY-329341 has ABL kinase inhibiting activities.
M20122 WAY-329340 WAY-329340 has ABL kinase inhibiting activities.
M20121 WAY-328158 WAY-328158 is a Inhibitor for BCR-ABL Kinase.
M20022 GI-560708 GI-560708 is a inhibitor of BCR-ABL tyrosine kinase.



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