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TG-100572 hydrochloride

Cat. No. M9067
TG-100572 hydrochloride Structure
Synonym:

TG-100572 HCl

Size Price Availability
5mg USD 280 1-2 Weeks
10mg USD 480 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

TG-100572 hydrochloride has IC50 values of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src and Yes, respectively. TG-100572 inhibits vascular endothelial cell proliferation (ED50=610±71 nM) and blocks VEGF-induced phosphorylation of extracellular signal-regulated kinase. TG100572 inhibits Src kinases and selected receptor tyrosine kinases, induced apoptosis of proliferating endothelial cells in vitro. TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV-induced angiogenesis and significantly reduced the severity of SK lesions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 512.43
Formula C26H27Cl2N5O2
CAS Number 867331-64-4
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

An anti-inflammatory role of VEGFR2/Src kinase inhibitor in herpes simplex virus 1-induced immunopathology.
Sharma S, et al. J Virol. 2011 Jun;85(12):5995-6007. PMID: 21471229.

Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema.
Doukas J, et al. J Cell Physiol. 2008 Jul;216(1):29-37. PMID: 18330892.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TG-100572 hydrochloride, TG-100572 HCl supplier, Src-bcr-Abl, inhibitors

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