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Tirbanibulin dihydrochloride

Cat. No. M14912
Tirbanibulin dihydrochloride Structure
Synonym:

KX2-391 dihydrochloride; KX-01 dihydrochloride

Size Price Availability
5mg USD 70  USD70 4-7 Days
10mg USD 90  USD90 4-7 Days
50mg USD 400  USD400 4-7 Days
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Quality Control & Documentation
Biological Activity

Tirbanibulin (dihydrochloride) (KX2-391 (dihydrochloride)) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.

Chemical Information
Molecular Weight 504.45
CAS Number 1038395-65-1
Solubility (25°C) Water 50 mg/mL
DMSO 33.33 mg/mL
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Tirbanibulin dihydrochloride, KX2-391 dihydrochloride; KX-01 dihydrochloride supplier, Src-bcr-Abl, inhibitors, activators


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