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Smo Smoothened

Cat.No.  Name Information
M1713 GDC-0449 (Vismodegib) GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.
M31262 MRT-81  MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.
M28245 MRT-83 hydrochloride  MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease.
M28092 MRT-83  MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling.
M14928 SAG SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
M9205 Glasdegib Glasdegib (PF-04449913) is a potent, orally bioavailable Smoothened (Smo) inhibitor with an IC50 of 4 nM.
M8977 MK-4101 MK-4101 is a novel SMO antagonist of the Hedgehog Pathway.
M4865 Smoothened Agonist (SAG) HCl Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
M4841 LDE225 (Sonidegib) diphosphate LDE225 Diphosphate (Sonidegib diphosphate) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
M4098 Saikosaponin-B1 Saikosaponin B1 is a bioactive ingredient of Bupleurum chinense with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in medulloblastoma (MB) models by targeting SMO to inhibit Hedgehog pathway.
M2997 SANT-1 SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.
M2750 Halcinonide Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent.
M2465 BMS-833923 BMS-833923 is an orally bioavailable Smoothened antagonist.
M1874 Purmorphamine Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO.
M43802 Glasdegib Maleate Glasdegib Maleate is an orally bioavailable Smoothened (Smo) inhibitor with an IC50 value of 4 nM for studies related to acute myeloid leukemia.
M30854 Fluticasone Fluticasone is a corticosteroid and Smo agonist with an IC50 of 99 nM, which activates the Hedgehog signaling pathway and promotes the proliferation of primary neural stem or precursor cells, and can be used in respiratory related studies.
M30177 HhAntag  HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway.
M28682 PF-5274857 hydrochloride  PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
M28238 ALLO-2  ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
M27940 LEQ506 LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.




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