Free shipping on all orders over $ 500

GSA-10

Cat. No. M8462
GSA-10 Structure
Synonym:

GSA10

Size Price Availability
1mg USD 185  USD185 4-7 Days
5mg USD 437  USD437 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

GSA-10 is a novel, potent activator of the smoothened receptor (Smo). GSA-10 acts on Smo to promote the differentiation of pluripotent mesenchymal stem cells into osteoblasts with an EC50 of 1.2 μM. GSA-10 binds to Smo at a unique site compared to agonists such as SAG and purmorphamine, and is not affected by the Smo antagonist cyclopamine. GSA-10 promotes the differentiation of mesenchymal pluripotent C3H10T1/2 cells into osteoblasts.

Chemical Information
Molecular Weight 450.53
Formula C26H30N2O5
CAS Number 300833-95-8
Solubility (25°C) DMSO: 0.5 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alice Del Giovane, et al. Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation

[2] Antonia Wiegering, et al. The Role of Hedgehog Signalling in the Formation of the Ventricular Septum

[3] Fabrizio Manetti, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

[4] Audrey Fleury, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway

[5] Tatiana Gorojankina, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened

Related Smo Products
Glasdegib Maleate

Glasdegib Maleate is an orally bioavailable Smoothened (Smo) inhibitor with an IC50 value of 4 nM for studies related to acute myeloid leukemia.

MRT-81 

MRT-81 is a potent antagonist of human and rodent smoothened (Smo) receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer.

Fluticasone

Fluticasone is a corticosteroid and Smo agonist with an IC50 of 99 nM, which activates the Hedgehog signaling pathway and promotes the proliferation of primary neural stem or precursor cells, and can be used in respiratory related studies.

HhAntag 

HhAntag is a specific, potent and orally active small molecule SMO antagonist of the Hh pathway.

PF-5274857 hydrochloride 

PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSA-10, GSA10 supplier, Smo, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.