Smo Smoothened

Cat.No.	Name	Information
M1713	GDC-0449 (Vismodegib)	GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively.
M4865	Smoothened Agonist (SAG) HCl	Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
M27940	LEQ506	LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively.
M14929	SAG dihydrochloride	SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; K_d=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
M11272	KAAD-Cyclopamine	Kaad-cyclopamine is an inhibitor of hedgehog signaling pathway and an antagonist of Smoothened.
M10835	Saridegib	Saridegib is a specific and effective inhibitor of Smo, a key transmembrane signaling protein in the Hedgehog pathway.