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BMS-833923

Cat. No. M2465
BMS-833923 Structure
Synonym:

XL139

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 220 In stock
100mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BMS-833923 is an orally bioavailable Smoothened antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 473.57
Formula C30H27N5O
CAS Number 1059734-66-5
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
Related Smo Products
SANT-1

SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-833923, XL139 supplier, Smo, inhibitors

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