| Cat.No. | Name | Information |
|---|---|---|
| M27630 | Azvudine | Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains. |
| M20784 | Tenofovir alafenamide fumarate | Tenofovir alafenamide (TAF, GS-7340) fumarate is a precursor compound of Tenofovir and a novel nucleotide reverse transcriptase inhibitor for use in studies related to HIV-1 infection. |
| M20577 | Doravirine | Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. |
| M20468 | Entecavir | Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
| M10188 | 2,2'-Cyclouridine | 2,2'-Cyclouridine is a research tool for antiviral and anticancer studies. |
| M5605 | Efavirenz | Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture. |
| M5051 | Tenofovir | Tenofovir is a nucleotide reverse transcriptase inhibitor used in studies related to HIV and chronic hepatitis B (HBV). |
| M5050 | Adefovir Dipivoxil | Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. |
| M3381 | Nevirapine | Nevirapine (NSC 641530) is a potent, specific non-nucleoside reverse transcriptase inhibitor (NNRTIs) that non-competitively inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with a Ki of 220 nM. Nevirapine (NSC 641530) can be used in AIDS-related researchs. |
| M3355 | Didanosine | Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
| M3352 | Lamivudine (BCH-189) | Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. |
| M3347 | Zalcitabine | Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
| M3342 | Emtricitabine | Emtricitabine is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. |
| M3205 | Zidovudine | Zidovudine is a reverse transcriptase inhibitor. |
| M2980 | Rilpivirine (R278474) | Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). |
| M2694 | Etravirine | Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
| M2575 | Dapivirine | Dapivirine is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations. |
| M2363 | Abacavir sulfate | Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
| M2137 | Stavudine | Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis. |
| M55842 | Tenofovir diphosphate | Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT). |
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