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Lamivudine

Cat. No. M3352

Lamivudine Structure
Size Price Availability Quantity
100mg USD 90 In stock
500mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lamivudine (Epivir) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.The pH-driven uptake of TEA by BBMV (pHin = 6.0, pHout = 7.5) was inhibited by lamivudine. The IC50 value (concentration resulting in 50% inhibition) for the concentration-dependent effect of lamivudine on TEA uptake by BBMV after 30 s was 2668 uM whereas IC50 values for cimetidine and trimethoprim were < 2.5 uM and < 25 uM, respectively. The early uptake of TEA by BLMV was also reduced significantly by lamivudine. The IC50 value for the concentration-dependent effect of lamivudine on uptake of TEA by BLMV at 30 s was > 25 mM, whereas the IC50 values for cimetidine and trimethoprim were 2116 uM and 445uM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 229.26
Formula C8H11N3O3S
CAS Number 134678-17-4
Purity >99%
Solubility DMSO 40 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017




Keywords: Lamivudine supplier, Reverse Transcriptase, inhibitors

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