Free shipping on all orders over $ 500
Didanosine (Videx, Videx EC) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. It is effective against HIV and used in combination with other antiretroviral compound therapy as part of highly active antiretroviral therapy (HAART).
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 236.23 |
| Formula | C10H12N4O3 |
| CAS Number | 69655-05-6 |
| Purity | >98% |
| Solubility | DMSO 40 mg/mL |
| Storage | at -20°C |
[2] David A Cooper. Update on didanosine
[3] R B Pollard. Didanosine once daily: potential for expanded use
| Related Reverse Transcriptase Products |
|---|
| Efavirenz
Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. |
| Adefovir Dipivoxil
Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
| Nevirapine
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
| Lamivudine
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM. |
| Zalcitabine
Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
