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M-MLV Reverse transcriptase

Cat. No. M41242
M-MLV Reverse transcriptase Structure
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Biological Activity

M-MLV Reverse transcriptase (M-MLV RT) is a kind of Reverse transcriptase, from the moroni mouse leukemia virus (MoMLV).

Chemical Information
CAS Number 9068-38-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zongliang Gao et al. Mol Ther. A truncated reverse transcriptase enhances prime editing by split AAV vectors

[2] Rachel M Hagen et al. Exp Mol Pathol. A M-MLV reverse transcriptase with reduced RNaseH activity allows greater sensitivity of gene expression detection in formalin fixed and paraffin embedded prostate cancer samples

[3] Arox Kamng'ona et al. J Enzyme Inhib Med Chem. Inhibition of HIV-1 and M-MLV reverse transcriptases by a major polyphenol (3,4,5 tri-O-galloylquinic acid) present in the leaves of the South African resurrection plant, Myrothamnus flabellifolia

[4] K Vastmans et al. Nucleic Acids Res. Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

[5] M G Cusi et al. Biotechniques. Comparison of M-MLV reverse transcriptase and Tth polymerase activity in RT-PCR of samples with low virus burden

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Keywords: M-MLV Reverse transcriptase supplier, Reverse Transcriptase, inhibitors, activators

 
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