Free shipping on all orders over $ 500

Efavirenz

Cat. No. M5605

Efavirenz Structure

Synonym: Sustiva, Stocrin, DMP-266, DMP 266

Size Price Availability Quantity
5mg USD 60 In stock
10mg USD 90 In stock
50mg USD 360 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 315.67
Formula C14H9ClF3NO2
CAS Number 154598-52-4
Purity >99%
Solubility 63 mg/mL in DMSO
Storage at -20°C
References

Efavirenz-Based Regimens in Antiretroviral-Naive HIV-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Kryst J, et al. PLoS One. 2015 May 1;10(5):e0124279. PMID: 25933004.

Related Reverse Transcriptase Products
Adefovir Dipivoxil

Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).

Nevirapine

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.

Didanosine

Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

Lamivudine

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM.

Zalcitabine

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Efavirenz, Sustiva, Stocrin, DMP-266, DMP 266 supplier, Reverse Transcriptase, inhibitors

Contact Us
  • Tel: +1-800-660-8580
  • Email: sales@abmole.com
  • Tel: +32 (0)2 738 09 61
  • Email: eu.order@abmole.com

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.