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Efavirenz

Cat. No. M5605
Efavirenz Structure
Synonym:

Sustiva, Stocrin, DMP-266, DMP 266

Size Price Availability Quantity
5mg USD 48  USD60 In stock
10mg USD 72  USD90 In stock
50mg USD 288  USD360 In stock
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Quality Control
Biological Activity

Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 315.67
Formula C14H9ClF3NO2
CAS Number 154598-52-4
Purity 100.0%
Solubility 63 mg/mL in DMSO
Storage at -20°C
References

[1] Kryst J, et al. PLoS One. Efavirenz-Based Regimens in Antiretroviral-Naive HIV-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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Keywords: Efavirenz, Sustiva, Stocrin, DMP-266, DMP 266 supplier, Reverse Transcriptase, inhibitors

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