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Stavudine

Cat. No. M2137
Stavudine Structure
Synonym:

d4T

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 35  USD35 In stock
100mg USD 60  USD60 In stock
200mg USD 85  USD85 In stock
500mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Stavudine (d4T, brand name Zerit) is an orally bioavailable nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. Stavudine triphosphate inhibits the HIV reverse transcriptase in vitro by competing with natural substrate, thymidine triphosphate. Stavudine also causes termination of DNA replication by incorporating into the DNA strand. In clinical studies, stavudine has excellent oral bioavailability in excess of 80%.

Chemical Information
Molecular Weight 224.21
Formula C10H12N2O4
CAS Number 3056-17-5
Solubility (25°C) DMSO 40 mg/mL
Water 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wangsomboonsiri W, et al. Clin Infect Dis. Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen.

[2] Riddler SA, et al. Antiviral Res. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T).

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Keywords: Stavudine, d4T supplier, Reverse Transcriptase, inhibitors, activators


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