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Abmole Inhibitor Catalog 2017

PKC Protein Kinase C

Inhibitors

Cat.No.  Name Information
M5319 Chelerythrine Chloride Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
M5303 1-Naphthyl PP1 1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).
M5032 Zoledronic acid monohydrate Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 uM.
M5030 Ingenol Mebutate Ingenol Mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.
M4647 12-O-tetradecanoyl-phorbol-13-acetate 12-O-tetradecanoyl-phorbol-13-acetate
M3804 Ro 31-8220 Ro 31-8220 is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively).
M3803 Sotrastaurin Sotrastaurin is a potent and selective small-molecule inhibitor of protein kinase C (PKC) with Ki value of 0.22 nM for PKCθ.
M3802 GF 109203X GF 109203X is a very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively).
M3799 UCN-02 UCN-02 is an inhibitor of PKC and PKA with IC50 values of 0.062 and 0.25 microM, respectively.
M3756 Oncrasin-1 Oncrasin-1 is a small molecule RNA polymerase II inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations.
M3694 arcyriarubin A arcyriarubin A is a cell permeable protein kinase C (PKC) inhibitor.
M3629 LY333531 hydrochloride LY333531 hydrochloride competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively).
M3625 Go6976 Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively).
M2982 Ro 31-8220 Mesylate Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.
M2850 Midostaurin Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.
M2620 Dequalinium Chloride Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 μM, and also a selective blocker of apamin-sensitive K+ channels with IC50 of 1.1 μM.
M2329 Zoledronic acid Zoledronic Acid is a potent nitrogen-containing bisphosphonates of human foetal osteoblastic cell line with an IC50 of 40 μM.
M2066 Staurosporine Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively.
M2019 Go 6983 Go 6983 is a fast acting, lipid soluble, broad spectrum protein kinase C inhibitor.
M1861 CX-4945 CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2).
M1704 Enzastaurin Enzastaurin inhibits PKCβ, PKCα, PKCγ and PKCε with IC50's of 0.006, 0.039, 0.083 and 0.110 µM, respectively.


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