Zoledronic Acid is a potent nitrogen-containing bisphosphonates of human foetal osteoblastic cell line with an IC50 of 40 μM. Zoledronic acid induces antiproliferative and apoptotic effects on multiple myeloma cell lines in vitro, by activating protein kinase C, and increases the extracellular calcium concentration. Zoledronic acid and radiation caused a dosedependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 μM and 20μM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation).
Nat Commun. 2023 Mar 14;14(1):1413.
BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism
Zoledronic acid purchased from AbMole
| Molecular Weight | 272.09 |
| Formula | C5H10N2O7P2 |
| CAS Number | 118072-93-8 |
| Solubility (25°C) | Water 4 mg/mL (ultrasonic and warming and adjust pH to 6 with NaOH) |
| Storage | 2-8°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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