| Cat.No. | Name | Information |
|---|---|---|
| M3629 | LY333531 hydrochloride | LY333531 hydrochloride competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). |
| M2066 | Staurosporine (AM-2282) | Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| M2850 | Midostaurin | Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. |
| M4647 | Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| M5032 | Zoledronic acid monohydrate | Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 uM. |
| M2329 | Zoledronic acid | Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. |
| M2790 | K252a | K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. |
| M53295 | Protein Kinase C (661-671) | Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). |
| M53294 | Protein kinase C substrate | Protein kinase C substrate is a substrate of Protein kinase C, can be used to detect protein. |
| M53293 | Protein Kinase C β Peptide | Protein Kinase C (beta) Peptide is a peptide fragment of Protein Kinase Cβ. |
| M53292 | Protein Kinase C γ Peptide | Protein Kinase C (gamma) Peptide is a peptide fragment of Protein Kinase Cγ. |
| M53291 | Ac-MBP (4-14) Peptide | Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. |
| M53290 | N-myristoyl-RKRTLRRL | N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. |
| M53289 | Pep2m, myristoylated | Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. |
| M53288 | PKCε (85-92) | PKCε (85-92) is a biological active peptide. |
| M53287 | SAMβA | SAMβA is conjugated to the cell permeable peptide TAT47-57. |
| M41726 | AJH-836 | AJH-836 is an activator of Munc13-1 and PKC ε/α (Kd: 4.5 nM for PKCα) . |
| M41725 | Anemonin | Anemonin (Pulsatilla camphor), a selective iNOS inhibitor, is also a PKC-θ inhibitor. |
| M41240 | HIV-1 protease-IN-10 | HIV-1 protease-IN-10 has HIV-1 latency reversing activity (IC50: 0.22 μM). |
| M38801 | Isojacareubin | Isojacareubin can be isolated from Hypericum japonicum. Isojacareubin covalently inhibits SARS-CoV-2 3CLpro. Isojacareubin also has anti-helicobacter activity. Isojacareubin inhibits PKC, and suppresses hepatocellular carcinoma metastasis and induces apoptosis. |
| M30630 | p32 Inhibitor M36 | p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1. |
| M30542 | Vibsanin A | Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor. |
| M29903 | N-Desmethyltamoxifen | N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. |
| M29437 | CRT0066854 hydrochloride | CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
| M28943 | Sangivamycin | Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers. |
| M28602 | BJE6-106 | BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect. |
| M28439 | CRT0066854 | CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively. |
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